diff --git a/django/http/response.py b/django/http/response.py
index 17b8da4da179..12cf47b1c14d 100644
--- a/django/http/response.py
+++ b/django/http/response.py
@@ -32,6 +32,7 @@
 _charset_from_content_type_re = _lazy_re_compile(
     r";\s*charset=(?P<charset>[^\s;]+)", re.I
 )
+_control_chars_re = _lazy_re_compile(r"[\x00-\x1f\x7f-\x9f]")
 
 
 class ResponseHeaders(CaseInsensitiveMapping):
@@ -142,7 +143,7 @@ def __init__(
 
             if not 100 <= self.status_code <= 599:
                 raise ValueError("HTTP status code must be an integer from 100 to 599.")
-        self._reason_phrase = reason
+        self.reason_phrase = reason
 
     @property
     def reason_phrase(self):
@@ -154,6 +155,8 @@ def reason_phrase(self):
 
     @reason_phrase.setter
     def reason_phrase(self, value):
+        if value and _control_chars_re.search(value):
+            raise BadHeaderError("reason_phrase can't contain control characters.")
         self._reason_phrase = value
 
     @property
diff --git a/tests/responses/tests.py b/tests/responses/tests.py
index b16cb533648e..05df257b3e6f 100644
--- a/tests/responses/tests.py
+++ b/tests/responses/tests.py
@@ -2,7 +2,7 @@
 
 from django.conf import settings
 from django.core.cache import cache
-from django.http import HttpResponse
+from django.http import BadHeaderError, HttpResponse
 from django.http.response import HttpResponseBase
 from django.test import SimpleTestCase
 
@@ -103,6 +103,20 @@ def test_reason_phrase(self):
         self.assertEqual(resp.status_code, 419)
         self.assertEqual(resp.reason_phrase, reason)
 
+    def test_invalid_reason_phrase(self):
+        msg = "reason_phrase can't contain control characters."
+        invalid_reasons = [
+            "OK\r\nX-Injected-header: yes",
+            "OK\x00",
+            "OK\x1f",
+            "OK\x7f",
+            "OK\x9f",
+        ]
+        for reason in invalid_reasons:
+            with self.subTest(reason=reason):
+                with self.assertRaisesMessage(BadHeaderError, msg):
+                    HttpResponse(reason=reason)
+
     def test_charset_detection(self):
         """HttpResponse should parse charset from content_type."""
         response = HttpResponse("ok")