diff --git a/src/api/providers/__tests__/bedrock-custom-arn.spec.ts b/src/api/providers/__tests__/bedrock-custom-arn.spec.ts
index dfad54c1fd..a24a863294 100644
--- a/src/api/providers/__tests__/bedrock-custom-arn.spec.ts
+++ b/src/api/providers/__tests__/bedrock-custom-arn.spec.ts
@@ -163,6 +163,32 @@ describe("Bedrock ARN Handling", () => {
 			expect(result.crossRegionInference).toBe(false)
 		})
 
+		it("should correctly extract modelType and modelId from application-inference-profile ARN", () => {
+			const handler = createHandler()
+			const arn =
+				"arn:aws:bedrock:eu-west-1:123456789012:application-inference-profile/abcd1234-ef56-7890-abcd-ef1234567890"
+
+			const result = (handler as any).parseArn(arn, "eu-west-1")
+
+			expect(result.isValid).toBe(true)
+			expect(result.modelType).toBe("application-inference-profile")
+			expect(result.modelId).toBe("abcd1234-ef56-7890-abcd-ef1234567890")
+			expect(result.region).toBe("eu-west-1")
+			expect(result.crossRegionInference).toBe(false)
+		})
+
+		it("should correctly parse application-inference-profile ARN with alphanumeric profile ID", () => {
+			const handler = createHandler()
+			const arn = "arn:aws:bedrock:us-west-2:123456789012:application-inference-profile/my-custom-profile"
+
+			const result = (handler as any).parseArn(arn, "us-west-2")
+
+			expect(result.isValid).toBe(true)
+			expect(result.modelType).toBe("application-inference-profile")
+			expect(result.modelId).toBe("my-custom-profile")
+			expect(result.crossRegionInference).toBe(false)
+		})
+
 		it("should return isValid: false for simple ARN format", () => {
 			const handler = createHandler()
 			const arn = "arn:aws:bedrock:us-east-1:123456789012:some-other-resource"
@@ -228,6 +254,23 @@ describe("Bedrock ARN Handling", () => {
 			expect((handler as any).client.config.region).toBe("eu-west-1")
 		})
 
+		it("should use full ARN as model ID for application-inference-profile ARNs", () => {
+			const arn =
+				"arn:aws:bedrock:eu-west-1:123456789012:application-inference-profile/abcd1234-ef56-7890-abcd-ef1234567890"
+			const handler = createHandler({
+				awsCustomArn: arn,
+				awsRegion: "eu-west-1",
+			})
+
+			const model = handler.getModel()
+
+			// For application-inference-profile ARNs, the full ARN should be used as the model ID
+			expect(model.id).toBe(arn)
+			expect(model.info).toHaveProperty("maxTokens")
+			expect(model.info).toHaveProperty("contextWindow")
+			expect(model.info.supportsImages).toBe(true)
+		})
+
 		it("should log region mismatch warning when ARN region differs from provided region", () => {
 			// Spy on logger.info which is called when there's a region mismatch
 			const infoSpy = vitest.spyOn(logger, "info")
diff --git a/src/api/providers/bedrock.ts b/src/api/providers/bedrock.ts
index 3ceb251003..6569e8b84c 100644
--- a/src/api/providers/bedrock.ts
+++ b/src/api/providers/bedrock.ts
@@ -923,6 +923,7 @@ export class AwsBedrockHandler extends BaseProvider implements SingleCompletionH
 		 *  - Prompt Router: arn:aws:bedrock:us-west-2:123456789012:prompt-router/anthropic-claude
 		 *  - Inference Profile: arn:aws:bedrock:us-west-2:123456789012:inference-profile/anthropic.claude-v2
 		 *  - Cross Region Inference Profile: arn:aws:bedrock:us-west-2:123456789012:inference-profile/us.anthropic.claude-3-5-sonnet-20241022-v2:0
+		 *  - Application Inference Profile: arn:aws:bedrock:eu-west-1:123456789012:application-inference-profile/my-profile-id
 		 *  - Custom Model (Provisioned Throughput): arn:aws:bedrock:us-west-2:123456789012:provisioned-model/my-custom-model
 		 *  - Imported Model: arn:aws:bedrock:us-west-2:123456789012:imported-model/my-imported-model
 		 *
@@ -1025,6 +1026,18 @@ export class AwsBedrockHandler extends BaseProvider implements SingleCompletionH
 				id: bedrockDefaultPromptRouterModelId,
 				info: JSON.parse(JSON.stringify(bedrockModels[bedrockDefaultPromptRouterModelId])),
 			}
+		} else if (modelType === "application-inference-profile") {
+			// Application inference profiles use opaque IDs (often UUIDs) that don't reveal the underlying model.
+			// Provide reasonable defaults assuming the underlying model is likely a modern Claude model,
+			// since that's the most common use case for Bedrock application inference profiles.
+			model = {
+				id: bedrockDefaultModelId,
+				info: {
+					...JSON.parse(JSON.stringify(bedrockModels[bedrockDefaultModelId])),
+					supportsImages: true,
+					supportsPromptCache: false,
+				},
+			}
 		} else {
 			// Use heuristics for model info, then allow overrides from ProviderSettings
 			const guessed = this.guessModelInfoFromId(modelId)
@@ -1318,7 +1331,8 @@ Please verify:
 2. If using an ARN, verify the ARN is correct and points to a valid model
 3. Your AWS credentials have permission to access this model (check IAM policies)
 4. The region in the ARN matches the region where the model is deployed
-5. If using a provisioned model, ensure it's active and not in a failed state`,
+5. If using a provisioned model, ensure it's active and not in a failed state
+6. If using an application inference profile, enter the full ARN in the "Custom ARN" field (not the model selector)`,
 			logLevel: "error",
 		},
 		NOT_FOUND: {
diff --git a/webview-ui/src/components/settings/providers/BedrockCustomArn.tsx b/webview-ui/src/components/settings/providers/BedrockCustomArn.tsx
index 7ace93c843..cfdf2a1502 100644
--- a/webview-ui/src/components/settings/providers/BedrockCustomArn.tsx
+++ b/webview-ui/src/components/settings/providers/BedrockCustomArn.tsx
@@ -34,6 +34,7 @@ export const BedrockCustomArn = ({ apiConfiguration, setApiConfigurationField }:
 					<li>
 						arn:aws:bedrock:eu-west-1:123456789012:inference-profile/eu.anthropic.claude-3-7-sonnet-20250219-v1:0
 					</li>
+					<li>arn:aws:bedrock:eu-west-1:123456789012:application-inference-profile/your-profile-id</li>
 					<li>arn:aws:bedrock:us-west-2:123456789012:provisioned-model/my-provisioned-model</li>
 					<li>arn:aws:bedrock:us-east-1:123456789012:default-prompt-router/anthropic.claude:1</li>
 				</ul>